Serum-free Erythroid Differentiation for Efficient Genetic Modification and High-Level Adult Hemoglobin Production

In vitro erythroid differentiation from primary human cells is valuable to develop genetic strategies for hemoglobin disorders. However, current erythroid differentiation methods are encumbered by modest transduction rates and high baseline fetal hemoglobin production. In this study, we sought to im...

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Опубликовано в: :Mol Ther Methods Clin Dev
Главные авторы: Uchida, Naoya, Demirci, Selami, Haro-Mora, Juan J., Fujita, Atsushi, Raines, Lydia N., Hsieh, Matthew M., Tisdale, John F.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Gene & Cell Therapy 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5948232/
https://ncbi.nlm.nih.gov/pubmed/29766032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2018.03.007
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