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Design, Synthesis and Evaluation of Oxazaborine Inhibitors of the NLRP3 Inflammasome
The NLRP3 inflammasome is an important regulator of the sterile inflammatory response, and its activation by host‐derived sterile molecules leads to the intracellular activation of caspase‐1, processing of the pro‐inflammatory cytokines interleukin‐1β (IL‐1β)/IL‐18, and pyroptotic cell death. Inappr...
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| Veröffentlicht in: | ChemMedChem |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
John Wiley and Sons Inc.
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5947144/ https://ncbi.nlm.nih.gov/pubmed/29331080 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201700731 |
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