LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation

The NLRP3 inflammasome is a multi-molecular protein complex that converts inactive cytokine precursors into active forms of IL-1β and IL-18. The NLRP3 inflammasome is frequently associated with the damaging inflammation of non-communicable disease states and is considered an attractive therapeutic t...

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Vydáno v:eLife
Hlavní autoři: Green, Jack P, Swanton, Tessa, Morris, Lucy V, El-Sharkawy, Lina Y, Cook, James, Yu, Shi, Beswick, James, Adamson, Antony D, Humphreys, Neil E, Bryce, Richard, Freeman, Sally, Lawrence, Catherine, Brough, David
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2020
Témata:
Immunology and Inflammation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7679132/
https://ncbi.nlm.nih.gov/pubmed/33216713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.59704
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