Selective inhibition of the K(+) efflux sensitive NLRP3 pathway by Cl(−) channel modulation

The NLRP3 inflammasome regulates production of the pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18, and contributes to inflammation exacerbating disease. Fenamate non-steroidal anti-inflammatory drugs (NSAIDs) were recently described as NLRP3 inflammasome inhibitors via chloride channel...

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Vydáno v:Chem Sci
Hlavní autoři: Swanton, Tessa, Beswick, James A., Hammadi, Halah, Morris, Lucy, Williams, Daniel, de Cesco, Stephane, El-Sharkawy, Lina, Yu, Shi, Green, Jack, Davis, John B., Lawrence, Catherine B., Brough, David, Freeman, Sally
Médium: Artigo
Jazyk:Inglês
Vydáno: The Royal Society of Chemistry 2020
Témata:
Chemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8162947/
https://ncbi.nlm.nih.gov/pubmed/34094411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc03828h
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