Translocon declogger Ste24 protects against IAPP oligomer-induced proteotoxicity

Aggregates of human islet amyloid polypeptide (IAPP) in the pancreas of patients with type-2 diabetes (T2D) are thought to contribute to β-cell dysfunction and death. To understand how IAPP harms cells and how this might be overcome, we created a yeast model of IAPP toxicity. Ste24, an evolutionaril...

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Vydáno v:Cell
Hlavní autoři: Kayatekin, Can, Amasino, Audra, Gaglia, Giorgio, Flannick, Jason, Bonner, Julia M., Fanning, Saranna, Narayan, Priyanka, Barrasa, M. Inmaculada, Pincus, David, Landgraf, Dirk, Nelson, Justin, Hesse, William R., Costanzo, Michael, Myers, Chad L., Boone, Charles, Florez, Jose C., Lindquist, Susan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5945206/
https://ncbi.nlm.nih.gov/pubmed/29526462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.02.026
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