Translocon declogger Ste24 protects against IAPP oligomer-induced proteotoxicity

Aggregates of human islet amyloid polypeptide (IAPP) in the pancreas of patients with type-2 diabetes (T2D) are thought to contribute to β-cell dysfunction and death. To understand how IAPP harms cells and how this might be overcome, we created a yeast model of IAPP toxicity. Ste24, an evolutionaril...

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Bibliografski detalji
Izdano u:Cell
Glavni autori: Kayatekin, Can, Amasino, Audra, Gaglia, Giorgio, Flannick, Jason, Bonner, Julia M., Fanning, Saranna, Narayan, Priyanka, Barrasa, M. Inmaculada, Pincus, David, Landgraf, Dirk, Nelson, Justin, Hesse, William R., Costanzo, Michael, Myers, Chad L., Boone, Charles, Florez, Jose C., Lindquist, Susan
Format: Artigo
Jezik:Inglês
Izdano: 2018
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5945206/
https://ncbi.nlm.nih.gov/pubmed/29526462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.02.026
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