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RAGE binds preamyloid IAPP intermediates and mediates pancreatic β cell proteotoxicity
Islet amyloidosis is characterized by the aberrant accumulation of islet amyloid polypeptide (IAPP) in pancreatic islets, resulting in β cell toxicity, which exacerbates type 2 diabetes and islet transplant failure. It is not fully clear how IAPP induces cellular stress or how IAPP-induced toxicity...
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Pubblicato in: | J Clin Invest |
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Autori principali: | , , , , , , , , , , , , , |
Natura: | Artigo |
Lingua: | Inglês |
Pubblicazione: |
American Society for Clinical Investigation
2018
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Soggetti: | |
Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5785261/ https://ncbi.nlm.nih.gov/pubmed/29337308 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI85210 |
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