RAGE binds preamyloid IAPP intermediates and mediates pancreatic β cell proteotoxicity

Islet amyloidosis is characterized by the aberrant accumulation of islet amyloid polypeptide (IAPP) in pancreatic islets, resulting in β cell toxicity, which exacerbates type 2 diabetes and islet transplant failure. It is not fully clear how IAPP induces cellular stress or how IAPP-induced toxicity...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Abedini, Andisheh, Cao, Ping, Plesner, Annette, Zhang, Jinghua, He, Meilun, Derk, Julia, Patil, Sachi A., Rosario, Rosa, Lonier, Jacqueline, Song, Fei, Koh, Hyunwook, Li, Huilin, Raleigh, Daniel P., Schmidt, Ann Marie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5785261/
https://ncbi.nlm.nih.gov/pubmed/29337308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI85210
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