Discovery of the Tyrobetaine Natural Products and Their Biosynthetic Gene Cluster via Metabologenomics

Natural products (NPs) are a rich source of medicines, but traditional discovery methods are often unsuccessful due to high rates of rediscovery. Genetic approaches for NP discovery are promising, but progress has been slow due to the difficulty of identifying unique biosynthetic gene clusters (BGCs...

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Publicado en:ACS Chem Biol
Autores principales: Parkinson, Elizabeth I., Tryon, James H., Goering, Anthony W., Ju, Kou-San, McClure, Ryan A., Kemball, Jeremy D., Zhukovsky, Sara, Labeda, David P., Thomson, Regan J., Kelleher, Neil L., Metcalf, William W.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5944846/
https://ncbi.nlm.nih.gov/pubmed/29510029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b01089
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