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Discovery of the Tyrobetaine Natural Products and Their Biosynthetic Gene Cluster via Metabologenomics

Natural products (NPs) are a rich source of medicines, but traditional discovery methods are often unsuccessful due to high rates of rediscovery. Genetic approaches for NP discovery are promising, but progress has been slow due to the difficulty of identifying unique biosynthetic gene clusters (BGCs...

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Dettagli Bibliografici
Pubblicato in:ACS Chem Biol
Autori principali: Parkinson, Elizabeth I., Tryon, James H., Goering, Anthony W., Ju, Kou-San, McClure, Ryan A., Kemball, Jeremy D., Zhukovsky, Sara, Labeda, David P., Thomson, Regan J., Kelleher, Neil L., Metcalf, William W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5944846/
https://ncbi.nlm.nih.gov/pubmed/29510029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b01089
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