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Strain-Specific Proteogenomics Accelerates Discovery of Natural Products Via Their Biosynthetic Pathways

The use of proteomics for direct detection of expressed pathways producing natural products has yielded many new compounds, even when used in a screening mode without a bacterial genome sequence available. Here we quantify the advantages of having draft DNA-sequence available for strain-specific pro...

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書目詳細資料
Main Authors: Albright, Jessica C., Goering, Anthony W., Doroghazi, James R., Metcalf, William W., Kelleher, Neil L.
格式: Artigo
語言:Inglês
出版: 2013
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946956/
https://ncbi.nlm.nih.gov/pubmed/24242000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10295-013-1373-4
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