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Strain-Specific Proteogenomics Accelerates Discovery of Natural Products Via Their Biosynthetic Pathways

The use of proteomics for direct detection of expressed pathways producing natural products has yielded many new compounds, even when used in a screening mode without a bacterial genome sequence available. Here we quantify the advantages of having draft DNA-sequence available for strain-specific pro...

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Detalhes bibliográficos
Main Authors: Albright, Jessica C., Goering, Anthony W., Doroghazi, James R., Metcalf, William W., Kelleher, Neil L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946956/
https://ncbi.nlm.nih.gov/pubmed/24242000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10295-013-1373-4
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