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Genome Mining and Metabolomics Uncover a Rare d-Capreomycidine Containing Natural Product and Its Biosynthetic Gene Cluster

We report the metabolomics-driven genome mining of a new cyclic-guanidino incorporating non-ribosomal peptide synthetase (NRPS) gene cluster and full structure elucidation of its associated hexapeptide product, faulknamycin. Structural studies unveiled that this natural product contained the previou...

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Publicat a:ACS Chem Biol
Autors principals: Tryon, James H., Rote, Jennifer C., Chen, Li, Robey, Matthew T., Vega, Marvin M., Phua, Wan Cheng, Metcalf, William W., Ju, Kou-San, Kelleher, Neil L., Thomson, Regan J.
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7830813/
https://ncbi.nlm.nih.gov/pubmed/33151679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.0c00663
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