BRD4 inhibition is synthetic lethal with PARP inhibitors through the induction of homologous recombination deficiency

Poly(ADP-ribose) polymerase inhibitors (PARPi) are selectively active in cells with homologous recombination (HR) deficiency (HRD) caused by mutations in BRCA1, BRCA2, and other pathway members. We sought small molecules that induce HRD in HR competent cells in order to induce synthetic lethality wi...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cancer Cell
Prif Awduron: Sun, Chaoyang, Yin, Jun, Fang, Yong, Chen, Jian, Jeong, Kang Jin, Chen, Xiaohua, Vellano, Christopher P., Ju, Zhenlin, Zhao, Wei, Zhang, Dong, Lu, Yiling, Meric-Bernstam, Funda, Yap, Timothy A., Hattersley, Maureen, O’Connor, Mark, Chen, Huawei, Fawell, Stephen, Lin, Shiaw-Yih, Peng, Guang, Mills, Gordon B.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5944839/
https://ncbi.nlm.nih.gov/pubmed/29533782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.01.019
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