Sequential therapy with PARP and WEE1 inhibitors minimizes toxicity while maintaining efficacy

We demonstrate that concurrent administration of poly (ADP-ribose) polymerase (PARP) and WEE1 inhibitors is effective in inhibiting tumor growth but poorly tolerated. Concurrent treatment with PARP and WEE1 inhibitors induces replication stress, DNA damage, and abrogates the G(2) DNA damage checkpoi...

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Bibliografske podrobnosti
izdano v:Cancer Cell
Main Authors: Fang, Yong, McGrail, Daniel J., Sun, Chaoyang, Labrie, Marilyne, Chen, Xiaohua, Zhang, Dong, Ju, Zhenlin, Vellano, Christopher P., Lu, Yiling, Li, Yongsheng, Jeong, Kang Jin, Ding, Zhiyong, Liang, Jiyong, Wang, Steven W., Dai, Hui, Lee, Sanghoon, Sahni, Nidhi, Mercado-Uribe, Imelda, Kim, Tae-beom, Chen, Ken, Lin, Shiaw-Yih, Peng, Guang, Westin, Shannon N., Liu, Jinsong, O’Connor, Mark J, Yap, Timothy A., Mills, Gordon B.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6642675/
https://ncbi.nlm.nih.gov/pubmed/31185210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.05.001
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