Sequential therapy with PARP and WEE1 inhibitors minimizes toxicity while maintaining efficacy

We demonstrate that concurrent administration of poly (ADP-ribose) polymerase (PARP) and WEE1 inhibitors is effective in inhibiting tumor growth but poorly tolerated. Concurrent treatment with PARP and WEE1 inhibitors induces replication stress, DNA damage, and abrogates the G(2) DNA damage checkpoi...

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Détails bibliographiques
Publié dans:Cancer Cell
Auteurs principaux: Fang, Yong, McGrail, Daniel J., Sun, Chaoyang, Labrie, Marilyne, Chen, Xiaohua, Zhang, Dong, Ju, Zhenlin, Vellano, Christopher P., Lu, Yiling, Li, Yongsheng, Jeong, Kang Jin, Ding, Zhiyong, Liang, Jiyong, Wang, Steven W., Dai, Hui, Lee, Sanghoon, Sahni, Nidhi, Mercado-Uribe, Imelda, Kim, Tae-beom, Chen, Ken, Lin, Shiaw-Yih, Peng, Guang, Westin, Shannon N., Liu, Jinsong, O’Connor, Mark J, Yap, Timothy A., Mills, Gordon B.
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6642675/
https://ncbi.nlm.nih.gov/pubmed/31185210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.05.001
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