BRD4 inhibition is synthetic lethal with PARP inhibitors through the induction of homologous recombination deficiency

Poly(ADP-ribose) polymerase inhibitors (PARPi) are selectively active in cells with homologous recombination (HR) deficiency (HRD) caused by mutations in BRCA1, BRCA2, and other pathway members. We sought small molecules that induce HRD in HR competent cells in order to induce synthetic lethality wi...

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Bibliographic Details
Published in:Cancer Cell
Main Authors: Sun, Chaoyang, Yin, Jun, Fang, Yong, Chen, Jian, Jeong, Kang Jin, Chen, Xiaohua, Vellano, Christopher P., Ju, Zhenlin, Zhao, Wei, Zhang, Dong, Lu, Yiling, Meric-Bernstam, Funda, Yap, Timothy A., Hattersley, Maureen, O’Connor, Mark, Chen, Huawei, Fawell, Stephen, Lin, Shiaw-Yih, Peng, Guang, Mills, Gordon B.
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5944839/
https://ncbi.nlm.nih.gov/pubmed/29533782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.01.019
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