Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2

p53 mediates the DNA damage response (DDR) by regulating the expression of genes implicated in cell cycle arrest, senescence, programmed cell death (PCD), and metabolism. Herein we demonstrate that human alkaline ceramidase 2 (ACER2) is a novel transcriptional target of p53 and that its transactivat...

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Pubblicato in:Cell Death Differ
Autori principali: Xu, Ruijuan, Garcia-Barros, Monica, Wen, Sally, Li, Fang, Lin, Chih-Li, Hannun, Yusuf A., Obeid, Lina M., Mao, Cungui
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5943524/
https://ncbi.nlm.nih.gov/pubmed/29229990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-017-0018-y
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