Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2

p53 mediates the DNA damage response (DDR) by regulating the expression of genes implicated in cell cycle arrest, senescence, programmed cell death (PCD), and metabolism. Herein we demonstrate that human alkaline ceramidase 2 (ACER2) is a novel transcriptional target of p53 and that its transactivat...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Cell Death Differ
Hlavní autoři: Xu, Ruijuan, Garcia-Barros, Monica, Wen, Sally, Li, Fang, Lin, Chih-Li, Hannun, Yusuf A., Obeid, Lina M., Mao, Cungui
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5943524/
https://ncbi.nlm.nih.gov/pubmed/29229990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-017-0018-y
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky