Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response

Human cells respond to DNA damage by elevating sphingosine, a bioactive sphingolipid that induces programmed cell death (PCD) in response to various forms of stress, but its regulation and role in the DNA damage response remain obscure. Herein we demonstrate that DNA damage increases sphingosine lev...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Xu, Ruijuan, Wang, Kai, Mileva, Izolda, Hannun, Yusuf A., Obeid, Lina M., Mao, Cungui
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4951300/
https://ncbi.nlm.nih.gov/pubmed/26943039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7825
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