In Vitro Pharmacological Characterization and In Vivo Validation of LSN3172176 a Novel M1 Selective Muscarinic Receptor Agonist Tracer Molecule for Positron Emission Tomography

In the search for improved symptomatic treatment options for neurodegenerative and neuropsychiatric diseases, muscarinic acetylcholine M1 receptors (M1 mAChRs) have received significant attention. Drug development efforts have identified a number of novel ligands, some of which have advanced to the...

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Vydáno v:J Pharmacol Exp Ther
Hlavní autoři: Mogg, Adrian J., Eessalu, Thomas, Johnson, Megan, Wright, Rebecca, Sanger, Helen E., Xiao, Hongling, Crabtree, Michael G., Smith, Alex, Colvin, Ellen M., Schober, Douglas, Gehlert, Donald, Jesudason, Cynthia, Goldsmith, Paul J., Johnson, Michael P., Felder, Christian C., Barth, Vanessa N., Broad, Lisa M.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2018
Témata:
Drug Discovery and Translational Medicine
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5941187/
https://ncbi.nlm.nih.gov/pubmed/29643252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.117.246454
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