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Heparin inhibits intracellular Mycobacterium tuberculosis bacterial replication by reducing iron levels in human macrophages

Iron is a crucial micronutrient for both mammals and their associated pathogens, and extensive literature has shown that Mycobacterium tuberculosis (Mtb) bacilli inhibited from acquiring iron from the host are severely attenuated. In contrast, increased dietary iron concentrations or patients with h...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Abreu, Rodrigo, Essler, Lauren, Loy, Allyson, Quinn, Frederick, Giri, Pramod
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940867/
https://ncbi.nlm.nih.gov/pubmed/29740038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-25480-y
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