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Role of the hepcidin-ferroportin axis in pathogen-mediated intracellular iron sequestration in human phagocytic cells

Upon infection, pathogen and host compete for the same iron pool, because this trace metal is a crucial micronutrient for all living cells. Iron dysregulation in the host is strongly associated with poor outcomes in several infectious diseases, including tuberculosis, AIDS, and malaria, and ineffici...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Abreu, Rodrigo, Quinn, Frederick, Giri, Pramod K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5965048/
https://ncbi.nlm.nih.gov/pubmed/29764842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017015255
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