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Protection by anti-viral memory CD8 T-cells requires rapidly produced antigen in large amounts()

Numerous attempts to produce anti-viral vaccines by harnessing memory CD8-T cells have failed. A barrier to progress is that we do not know what makes an antigen a viable target of protective CD8 T-cell memory. We found that in mice susceptible to lethal mousepox (the mouse homolog of human smallpox...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Remakus, Sanda, Ma, Xueying, Tang, Lingjuan, Xu, Ren-Huan, Knudson, Cory, Melo-Silva, Carolina R., Rubio, Daniel, Kuo, Yin-Ming, Andrews, Andrew, Sigal, Luis J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940544/
https://ncbi.nlm.nih.gov/pubmed/29643193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1701568
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