Molecular recognition of physiological substrate noradrenaline by the adrenaline synthesising enzyme PNMT and factors influencing its methyltransferase activity

Substrate specificity is critically important for enzyme catalysis. In the adrenaline synthesising enzyme phenylethanolamine N-methyltransferase (PNMT), minor changes in substituents can convert substrates into inhibitors. Here we report the crystal structures of 6 human PNMT complexes including the...

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Détails bibliographiques
Publié dans:Biochem J
Auteurs principaux: Drinkwater, Nyssa, Gee, Christine L., Puri, Munish, Criscione, Kevin R., McLeish, Michael J., Grunewald, Gary L., Martin, Jennifer L.
Format: Artigo
Langue:Inglês
Publié: 2009
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940352/
https://ncbi.nlm.nih.gov/pubmed/19570037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20090702
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