STRUCTURAL BASIS OF SUBSTRATE RECOGNITION IN THIOPURINE S-METHYLTRANSFERASE

Thiopurine S-methyltransferase (TPMT) modulates the cytotoxic effects of thiopurine prodrugs such as 6-mercaptopurine by methylating them in a reaction using S-adenosyl-L-methionine as the donor. Patients with TPMT variant allozymes exhibit diminished levels of protein and/or enzyme activity and are...

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Detaylı Bibliyografya
Asıl Yazarlar: Peng, Yi, Feng, Qiping, Wilk, Dennis, Adjei, Araba A., Salavaggione, Oreste E., Weinshilboum, Richard M., Yee, Vivien C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2008
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2447621/
https://ncbi.nlm.nih.gov/pubmed/18484748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800102x
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