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Molecular recognition of physiological substrate noradrenaline by the adrenaline synthesising enzyme PNMT and factors influencing its methyltransferase activity
Substrate specificity is critically important for enzyme catalysis. In the adrenaline synthesising enzyme phenylethanolamine N-methyltransferase (PNMT), minor changes in substituents can convert substrates into inhibitors. Here we report the crystal structures of 6 human PNMT complexes including the...
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| Publicado no: | Biochem J |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5940352/ https://ncbi.nlm.nih.gov/pubmed/19570037 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20090702 |
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