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Atom-by-atom tuning of the electrostatic potassium-channel modulator dehydroabietic acid
Dehydroabietic acid (DHAA) is a naturally occurring component of pine resin that was recently shown to open voltage-gated potassium (K(V)) channels. The hydrophobic part of DHAA anchors the compound near the channel’s positively charged voltage sensor in a pocket between the channel and the lipid me...
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| Udgivet i: | J Gen Physiol |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Rockefeller University Press
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5940250/ https://ncbi.nlm.nih.gov/pubmed/29626041 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201711965 |
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