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Coupling stabilizers open K(V)1-type potassium channels

The opening and closing of voltage-gated ion channels are regulated by voltage sensors coupled to a gate that controls the ion flux across the cellular membrane. Modulation of any part of gating constitutes an entry point for pharmacologically regulating channel function. Here, we report on the disc...

Ausführliche Beschreibung

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Silverå Ejneby, Malin, Wallner, Björn, Elinder, Fredrik
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7604479/
https://ncbi.nlm.nih.gov/pubmed/33051293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2007965117
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