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Drug-induced ion channel opening tuned by the voltage sensor charge profile

Polyunsaturated fatty acids modulate the voltage dependence of several voltage-gated ion channels, thereby being potent modifiers of cellular excitability. Detailed knowledge of this molecular mechanism can be used in designing a new class of small-molecule compounds against hyperexcitability diseas...

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Detaylı Bibliyografya
Asıl Yazarlar: Ottosson, Nina E., Liin, Sara I., Elinder, Fredrik
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Rockefeller University Press 2014
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4001773/
https://ncbi.nlm.nih.gov/pubmed/24420769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201311087
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