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Drug-induced ion channel opening tuned by the voltage sensor charge profile
Polyunsaturated fatty acids modulate the voltage dependence of several voltage-gated ion channels, thereby being potent modifiers of cellular excitability. Detailed knowledge of this molecular mechanism can be used in designing a new class of small-molecule compounds against hyperexcitability diseas...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4001773/ https://ncbi.nlm.nih.gov/pubmed/24420769 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201311087 |
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