Spliceosome profiling visualizes operations of a dynamic RNP at nucleotide resolution

Tools to understand how the spliceosome functions in vivo have lagged behind advances in its structural biology. Here, methods are described to globally profile spliceosome-bound pre-mRNA, intermediates and spliced mRNA at nucleotide resolution. These tools are applied three yeast species that span...

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Pubblicato in:Cell
Autori principali: Burke, Jordan E., Longhurst, Adam D., Merkurjev, Daria, Sales-Lee, Jade, Rao, Beiduo, Moresco, James, Yates, John, Li, Jingyi Jessica, Madhani, Hiten D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940017/
https://ncbi.nlm.nih.gov/pubmed/29727661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.03.020
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