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snRNA Catalysts in the Spliceosome’s Ancient Core
The spliceosome, an assembly of snRNAs and proteins, catalyzes the removal of introns from premessenger RNAs. A new study identifies specific phosphates in the U2–U6 snRNA complex that position two catalytic metals. Remarkably, these correspond precisely to metal-binding phosphates in a homologous s...
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2013
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| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4162089/ https://ncbi.nlm.nih.gov/pubmed/24315092 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.11.022 |
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