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snRNA Catalysts in the Spliceosome’s Ancient Core

The spliceosome, an assembly of snRNAs and proteins, catalyzes the removal of introns from premessenger RNAs. A new study identifies specific phosphates in the U2–U6 snRNA complex that position two catalytic metals. Remarkably, these correspond precisely to metal-binding phosphates in a homologous s...

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Bibliografiska uppgifter
Huvudupphovsman: Madhani, Hiten D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4162089/
https://ncbi.nlm.nih.gov/pubmed/24315092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.11.022
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