Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes

Legumain (AEP) is a lysosomal cysteine protease that is a lysosomal cysteine protease that was first characterized in leguminous seeds and later discovered in higher eukaryotes. AEP up-regulation is linked to a number of diseases including inflammation, arteriosclerosis and tumorigenesis. Thus legum...

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Veröffentlicht in:Cell Chem Biol
Hauptverfasser: Poreba, Marcin, Solberg, Rigmor, Rut, Wioletta, Lunde, Ngoc Nguyen, Kasperkiewicz, Paulina, Snipas, Scott J., Mihelic, Marko, Turk, Dusan, Turk, Boris, Salvesen, Guy S., Drag, Marcin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5939596/
https://ncbi.nlm.nih.gov/pubmed/27478158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2016.05.020
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