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Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling
The exploration of protease substrate specificity is generally restricted to naturally occurring amino acids, limiting the degree of conformational space that can be surveyed. We substantially enhanced this by incorporating 102 unnatural amino acids to explore the S1–S4 pockets of human neutrophil e...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3932852/ https://ncbi.nlm.nih.gov/pubmed/24550277 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1318548111 |
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