Dynamic activation and regulation of the mitogen-activated protein kinase p38

Mitogen-activated protein kinases, which include p38, are essential for cell differentiation and autophagy. The current model for p38 activation involves activation-loop phosphorylation with subsequent substrate binding leading to substrate phosphorylation. Despite extensive efforts, the molecular m...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Kumar, Ganesan Senthil, Clarkson, Michael W., Kunze, Micha B. A., Granata, Daniele, Wand, A. Joshua, Lindorff-Larsen, Kresten, Page, Rebecca, Peti, Wolfgang
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2018
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5939092/
https://ncbi.nlm.nih.gov/pubmed/29666261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1721441115
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