Interaction of Kinase-Interaction-Motif Protein Tyrosine Phosphatases with the Mitogen-Activated Protein Kinase ERK2

The mitogen-activation protein kinase ERK2 is tightly regulated by multiple phosphatases, including those of the kinase interaction motif (KIM) PTP family (STEP, PTPSL and HePTP). Here, we use small angle X-ray scattering (SAXS) and isothermal titration calorimetry (ITC) to show that the ERK2:STEP c...

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Autores principales: Francis, Dana M., Koveal, Dorothy, Tortajada, Antoni, Page, Rebecca, Peti, Wolfgang
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3956856/
https://ncbi.nlm.nih.gov/pubmed/24637728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0091934
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