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Resting and Active States of the ERK2:HePTP Complex
The MAP kinase ERK2 is regulated by numerous phosphatases that tightly control its activity. For example, the hematopoietic tyrosine phosphatase (HePTP) negatively regulates T cell activation in lymphocytes via ERK2 dephosphorylation. However, only very limited structural information is available fo...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3210578/ https://ncbi.nlm.nih.gov/pubmed/21985012 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja2075136 |
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