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Cooperative dynamics across distinct structural elements regulate PTP1B activity

Protein-tyrosine phosphatase 1B (PTP1B) is the canonical enzyme for investigating how distinct structural elements influence enzyme catalytic activity. Although it is recognized that dynamics are essential for PTP1B function, the data collected thus far have not resolved whether distinct elements ar...

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Vydáno v:J Biol Chem
Hlavní autoři: Torgeson, Kristiane R., Clarkson, Michael W., Kumar, Ganesan Senthil, Page, Rebecca, Peti, Wolfgang
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7535920/
https://ncbi.nlm.nih.gov/pubmed/32737198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014652
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