Conformational rigidity and protein dynamics at distinct timescales regulate PTP1B activity and allostery

Protein function originates from a cooperation of structural rigidity, dynamics at different timescales and allostery. However, how these three pillars of protein function are integrated is still only poorly understood. Here we show how these pillars are connected in Protein Tyrosine Phosphatase 1B...

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Publicado en:Mol Cell
Autores principales: Choy, Meng S., Li, Yang, Machado, Luciana E.S.F., Kunze, Micha B. A., Connors, Christopher R., Wei, Xingyu, Lindorff-Larsen, Kresten, Page, Rebecca, Peti, Wolfgang
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325675/
https://ncbi.nlm.nih.gov/pubmed/28212750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.01.014
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