Conformational rigidity and protein dynamics at distinct timescales regulate PTP1B activity and allostery

Protein function originates from a cooperation of structural rigidity, dynamics at different timescales and allostery. However, how these three pillars of protein function are integrated is still only poorly understood. Here we show how these pillars are connected in Protein Tyrosine Phosphatase 1B...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Mol Cell
Päätekijät: Choy, Meng S., Li, Yang, Machado, Luciana E.S.F., Kunze, Micha B. A., Connors, Christopher R., Wei, Xingyu, Lindorff-Larsen, Kresten, Page, Rebecca, Peti, Wolfgang
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2017
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325675/
https://ncbi.nlm.nih.gov/pubmed/28212750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.01.014
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