Conformational rigidity and protein dynamics at distinct timescales regulate PTP1B activity and allostery

Protein function originates from a cooperation of structural rigidity, dynamics at different timescales and allostery. However, how these three pillars of protein function are integrated is still only poorly understood. Here we show how these pillars are connected in Protein Tyrosine Phosphatase 1B...

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Detaylı Bibliyografya
Yayımlandı:Mol Cell
Asıl Yazarlar: Choy, Meng S., Li, Yang, Machado, Luciana E.S.F., Kunze, Micha B. A., Connors, Christopher R., Wei, Xingyu, Lindorff-Larsen, Kresten, Page, Rebecca, Peti, Wolfgang
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325675/
https://ncbi.nlm.nih.gov/pubmed/28212750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.01.014
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