The Radical S-Adenosylmethionine Methylase NosN Catalyzes both C1 Transfer and Formation of the Ester Linkage of the Side-Ring System during the Biosynthesis of Nosiheptide

Nosiheptide, a member of the e series of macrocyclic thiopeptide natural products, contains a side-ring system composed of a 3,4-dimethylindolic acid (DMIA) moiety connected to Glu6 and Cys8 of the thiopeptide back-bone via ester and thioester linkages, respectively. Herein, we show that NosN, a pre...

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Vydáno v:J Am Chem Soc
Hlavní autoři: LaMattina, Joseph W., Wang, Bo, Badding, Edward D., Gadsby, Lauren K., Grove, Tyler L., Booker, Squire J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5938625/
https://ncbi.nlm.nih.gov/pubmed/29039940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b08492
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