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Rerouting the Pathway for the Biosynthesis of the Side Ring System of Nosiheptide: The Roles of NosI, NosJ, and NosK

[Image: see text] Nosiheptide (NOS) is a highly modified thiopeptide antibiotic that displays formidable in vitro activity against a variety of Gram-positive bacteria. In addition to a central hydroxypyridine ring, NOS contains several other modifications, including multiple thiazole rings, dehydro-...

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Détails bibliographiques
Publié dans:J Am Chem Soc
Auteurs principaux: Badding, Edward D., Grove, Tyler L., Gadsby, Lauren K., LaMattina, Joseph W., Boal, Amie K., Booker, Squire J.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2017
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940322/
https://ncbi.nlm.nih.gov/pubmed/28343381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b01497
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