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Capturing Intermediates in the Reaction Catalyzed by NosN, a Class C Radical S-Adenosylmethionine Methylase Involved in the Biosynthesis of the Nosiheptide Side Ring System

Nosiheptide is a ribosomally synthesized and post-translationally modified thiopeptide natural product that possesses antibacterial, anticancer, and immunosuppressive properties. It contains a bicyclic structure composed of a large macrocycle and a unique side-ring system containing a 3,4-dimethylin...

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Bibliographic Details
Published in:J Am Chem Soc
Main Authors: Wang, Bo, LaMattina, Joseph W., Marshall, Savannah L., Booker, Squire J.
Format: Artigo
Language:Inglês
Published: 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7061316/
https://ncbi.nlm.nih.gov/pubmed/30865439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b13157
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