Nalaganje...
The Radical S-Adenosylmethionine Methylase NosN Catalyzes both C1 Transfer and Formation of the Ester Linkage of the Side-Ring System during the Biosynthesis of Nosiheptide
Nosiheptide, a member of the e series of macrocyclic thiopeptide natural products, contains a side-ring system composed of a 3,4-dimethylindolic acid (DMIA) moiety connected to Glu6 and Cys8 of the thiopeptide back-bone via ester and thioester linkages, respectively. Herein, we show that NosN, a pre...
Shranjeno v:
| izdano v: | J Am Chem Soc |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2017
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5938625/ https://ncbi.nlm.nih.gov/pubmed/29039940 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b08492 |
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