Qualitative and Quantitative Characterization of Composition Heterogeneity on the Surface of Spray Dried Amorphous Solid Dispersion Particles by an Advanced Surface Analysis Platform with High Surface Sensitivity and Superior Spatial Resolution

Surface composition critically impacts stability (e.g., crystallization) and performance (e.g., dissolution) of spray dried amorphous solid dispersion (ASD) formulations; however, traditional characterization techniques such as Raman and infrared spectroscopies may not provide useful information on...

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Bibliografische gegevens
Gepubliceerd in:Mol Pharm
Hoofdauteurs: Bhujbal, Sonal V., Zemlyanov, Dmitry Y., Cavallaro, Alex, Mangal, Sharad, Taylor, Lynne S., Zhou, Qi Tony
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5938120/
https://ncbi.nlm.nih.gov/pubmed/29641898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.8b00122
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