Discovery of Natural Products as Novel and Potent FXR Antagonists by Virtual Screening

Farnesoid X receptor (FXR) is a member of nuclear receptor family involved in multiple physiological processes through regulating specific target genes. The critical role of FXR as a transcriptional regulator makes it a promising target for diverse diseases, especially those related to metabolic dis...

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Bibliographische Detailangaben
Veröffentlicht in:Front Chem
Hauptverfasser: Diao, Yanyan, Jiang, Jing, Zhang, Shoude, Li, Shiliang, Shan, Lei, Huang, Jin, Zhang, Weidong, Li, Honglin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Chemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5936786/
https://ncbi.nlm.nih.gov/pubmed/29761098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2018.00140
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