Discovery of potent inhibitors for phosphodiesterase 5 by virtual screening and pharmacophore analysis

AIM: To explore the potent inhibitor from one of the Traditional Chinese medicine (TCM), Epimedium sagittatum. METHODS: We predicted the potent compound, ES03b, de novo evolution from the four Epimedium sagittatum components were verified by molecular docking, pharmacophore analysis, and analysis of...

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Bibliografische gegevens
Hoofdauteurs: Chen, Chien-yu, Chang, Yea-huey, Bau, Da-tian, Huang, Hung-jin, Tsai, Fuu-jen, Tsai, Chang-hai, Chen, Calvin Yu-chian
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2009
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Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4006686/
https://ncbi.nlm.nih.gov/pubmed/19597523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2009.100
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