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Discovery of potent and selective butyrylcholinesterase inhibitors through the use of pharmacophore-based screening
Cholinesterase inhibitors have long been used in the treatment of Alzheimer’s Disease (AD) via the protection of acetylcholine levels. However, recent research has shown that the specific inhibition of butyrylcholinesterase (BChE) could better ameliorate symptoms within patients. In addition, it has...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6953623/ https://ncbi.nlm.nih.gov/pubmed/31708262 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.126754 |
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