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Discovery of potent and selective butyrylcholinesterase inhibitors through the use of pharmacophore-based screening

Cholinesterase inhibitors have long been used in the treatment of Alzheimer’s Disease (AD) via the protection of acetylcholine levels. However, recent research has shown that the specific inhibition of butyrylcholinesterase (BChE) could better ameliorate symptoms within patients. In addition, it has...

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Dettagli Bibliografici
Pubblicato in:Bioorg Med Chem Lett
Autori principali: Williams, Alexander, Zhou, Shuo, Zhan, Chang-Guo
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6953623/
https://ncbi.nlm.nih.gov/pubmed/31708262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.126754
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