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Pharmacophore Modeling and Virtual Screening for the Discovery of New type 4 cAMP Phosphodiesterase (PDE4) Inhibitors

Type 4 cAMP phosphodiesterase (PDE4) inhibitors show a broad spectrum of anti-inflammatory effects in almost all kinds of inflamed cells, by an increase in cAMP levels which is a pivotal second messenger responsible for various biological processes. These inhibitors are now considered as the potenti...

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מידע ביבליוגרפי
Main Authors: Niu, Miaomiao, Dong, Fenggong, Tang, Shi, Fida, Guissi, Qin, Jingyi, Qiu, Jiadan, Liu, Kangbo, Gao, Weidong, Gu, Yueqing
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2013
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3858292/
https://ncbi.nlm.nih.gov/pubmed/24340020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0082360
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