Epigenetic regulation of NFE2 overexpression in myeloproliferative neoplasms

The transcription factor “nuclear factor erythroid 2” (NFE2) is overexpressed in the majority of patients with myeloproliferative neoplasms (MPNs). In murine models, elevated NFE2 levels cause an MPN phenotype with spontaneous leukemic transformation. However, both the molecular mechanisms leading t...

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Bibliografske podrobnosti
izdano v:Blood
Main Authors: Peeken, Jan C., Jutzi, Jonas S., Wehrle, Julius, Koellerer, Christoph, Staehle, Hans F., Becker, Heiko, Schoenwandt, Elias, Seeger, Thalia S., Schanne, Daniel H., Gothwal, Monika, Ott, Christopher J., Gründer, Albert, Pahl, Heike L.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2018
Teme:
Myeloid Neoplasia
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5934799/
https://ncbi.nlm.nih.gov/pubmed/29519804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-10-810622
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